Design of Highly Fluorinated Peptides for Cell-based ¹⁹F NMR.

ABSTRACT: The design of imaging agents with high fluorine content is essential for overcoming the challenges associated with signal detection limits in ¹⁹F MRI-based molecular imaging. In addition to perfluorocarbon and fluorinated polymers, fluorinated peptides offer an additional strategy for creating sequence-defined ¹⁹F magnetic resonance imaging (MRI) imaging agents with a high fluorine signal. Our previously reported unstructured trifluoroacetyllysine-based peptides possessed good physiochemical properties and could be imaged at high magnetic field strength. However, the low detection limit motivated further improvements in the fluorine content of the peptides as well as removal of nonspecific cellular interactions. This research characterizes several new highly fluorinat

SUBMITTER: Li J 

PROVIDER: S-EPMC10699466 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature