Circulating Exosomes and Ambient Air Pollution Exposure in COPD.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is characterized by progressive obstruction of airways due to chronic inflammation. Both genetic and environmental components are risk factors for COPD. The most common cause of COPD is smoking. However, evidence suggests that 17% to 38% of COPD patients are nonsmokers, so other factors like air pollution may also play a role.

Objective

The relationship between serum exosomes and exposure to particulate matter (PM) <2.5 and 10 micrometers (µm) in the residing environment of COPD patients and healthy groups was investigated. The correlation between inflammatory cytokine levels with exosome count was also studied.

Methods

Peripheral blood samples were taken from 20 COPD patients without a smoking history or a famil

SUBMITTER: Soleimanifar N 

PROVIDER: S-EPMC10699492 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature