IDP-LM: Prediction of protein intrinsic disorder and disorder functions based on language models.

ABSTRACT: Intrinsically disordered proteins (IDPs) and regions (IDRs) are a class of functionally important proteins and regions that lack stable three-dimensional structures under the native physiologic conditions. They participate in critical biological processes and thus are associated with the pathogenesis of many severe human diseases. Identifying the IDPs/IDRs and their functions will be helpful for a comprehensive understanding of protein structures and functions, and inform studies of rational drug design. Over the past decades, the exponential growth in the number of proteins with sequence information has deepened the gap between uncharacterized and annotated disordered sequences. Protein language models have recently demonstrated their powerful abilities to capture complex structural and f

SUBMITTER: Pang Y 

PROVIDER: S-EPMC10699601 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature