Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC10699647 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Zhang Xuan X Weiß Tina T Cheng Mary Hongying MH Chen Siqi S Ambrosius Carla Katharina CK Czerniak Anne Sophie AS Li Kunpeng K Feng Mingye M Bahar Ivet I Beck-Sickinger Annette G AG Zhang Cheng C
PLoS biology 20231206 12
Chemokine-like receptor 1 (CMKLR1), also known as chemerin receptor 23 (ChemR23) or chemerin receptor 1, is a chemoattractant G protein-coupled receptor (GPCR) that responds to the adipokine chemerin and is highly expressed in innate immune cells, including macrophages and neutrophils. The signaling pathways of CMKLR1 can lead to both pro- and anti-inflammatory effects depending on the ligands and physiological contexts. To understand the molecular mechanisms of CMKLR1 signaling, we determined a ...[more]