Adjuvant-attenuated symptom severity of influenza infections in vaccinated children.

ABSTRACT:

Background

Young children are at high risk for developing complications of influenza, as well as severe clinical presentation of disease. Vaccination provides direct protection and reduces symptom severity in breakthrough infections. We assessed whether adjuvanted trivalent seasonal influenza vaccine is associated with symptom severity in children who developed laboratory-confirmed influenza, as compared to children who received quadrivalent inactivated influenza.

Methods

A cluster randomized controlled trial of influenza vaccines in Canadian Hutterite colonies was conducted from the 2016-2017 to the 2018-2019 influenza season. Children were vaccinated with either quadrivalent inactivated influenza vaccine (QIV), or the MF59 adjuvanted trivalent influenza vaccine (aTIV). We

SUBMITTER: Switzer C 

PROVIDER: S-EPMC10699701 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature