Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to antifungal compounds.

ABSTRACT: Candida albicans, an opportunistic human pathogen, poses a significant threat to human health and is associated with significant socio-economic burden. Current antifungal treatments fail, at least in part, because C. albicans can initiate a strong drug tolerance response that allows some cells to grow at drug concentrations above their minimal inhibitory concentration. To better characterize this cytoprotective tolerance program at the molecular single-cell level, we used a nanoliter droplet-based transcriptomics platform to profile thousands of individual fungal cells and establish their subpopulation characteristics in the absence and presence of antifungal drugs. Profiles of untreated cells exhibit heterogeneous expression that correlates with cell cycle stage with distinc

SUBMITTER: Dumeaux V 

PROVIDER: S-EPMC10699808 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature