Patients' attitudes and preferences toward delayed disease progression in the absence of improved survival.

ABSTRACT:

Background

Cancer patients' attitudes toward progression-free survival (PFS) gains offered by treatment are not well understood, particularly in the absence of overall survival (OS) gains. The objectives were to describe patients' willingness to accept treatment that offers PFS gains without OS gains, to compare these findings with treatments offering OS gains, and to qualitatively summarize patients' reasons for their preferences.

Methods

A multicenter, cross-sectional, convergent mixed-methods study design recruited patients who had received at least 3 months of systemic therapy for incurable solid tumors. A treatment trade-off exercise determined the gains in imaging PFS that patients require to prefer additional systemic treatment for a scenario of a newly diagnosed, asy

SUBMITTER: Brundage MD 

PROVIDER: S-EPMC10699849 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature