Immune changes in hilar tumor draining lymph nodes following node sparing neoadjuvant chemoradiotherapy of localized cN0 non-small cell lung cancer.

ABSTRACT:

Background

While much progress has been accomplished in the understanding of radiation-induced immune effects in tumors, little is known regarding the mechanisms involved at the tumor draining lymph node (TDLN) level. The objective of this retrospective study was to assess the immune and biological changes arising in non-involved TDLNs upon node sparing concurrent chemoradiotherapy (CRT) of non-small cell lung cancer (NSCLC) tumors.

Methods

Patients with proven localized (cN0M0) NSCLC, treated by radical surgery plus lymph node dissection with (CRT⁺) or without (CRT^-) neoadjuvant chemoradiotherapy, whereby radiotherapy was targeted on the primary tumor with no significant incidental irradiation of the non-involved TDLN station (stations XI), were identi

SUBMITTER: Khalifa J 

PROVIDER: S-EPMC10699862 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature