Multi-omics approach for identifying CNV-associated lncRNA signatures with prognostic value in prostate cancer.

ABSTRACT:

Background

Prostate cancer, the second most prevalent malignancy among men, poses a significant threat to affected patients' well-being due to its poor prognosis. Novel biomarkers are required to enhance clinical outcomes and tailor personalized treatments. Herein, we describe our research to explore the prognostic value of long non-coding RNAs (lncRNAs) deregulated by copy number variations (CNVs) in prostate cancer.

Methods

The study employed an integrative multi-omics data analysis of the prostate cancer transcriptomic, CNV and methylation datasets to identify prognosis-related subtypes. Subtype-specific expression profiles of protein-coding genes (PCGs) and lncRNAs were determined. We analysed CNV patterns of lncRNAs across the genome to identify subtype-specific lncRNAs

SUBMITTER: Tyagi N 

PROVIDER: S-EPMC10700122 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature