MSL2 ensures biallelic gene expression in mammals.

ABSTRACT: In diploid organisms, biallelic gene expression enables the production of adequate levels of mRNA^1,2. This is essential for haploinsufficient genes, which require biallelic expression for optimal function to prevent the onset of developmental disorders^1,3. Whether and how a biallelic or monoallelic state is determined in a cell-type-specific manner at individual loci remains unclear. MSL2 is known for dosage compensation of the male X chromosome in flies. Here we identify a role of MSL2 in regulating allelic expression in mammals. Allele-specific bulk and single-cell analyses in mouse neural progenitor cells revealed that, in addition to the targets showing biallelic downregulation, a class of genes transitions from biallelic to monoallelic expression after MSL2 loss.

SUBMITTER: Sun Y 

PROVIDER: S-EPMC10700137 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature