Fusing Positive and Negative CT Contrast Nanoagent for the Sensitive Detection of Hepatoma.

ABSTRACT: Positive computed tomography (CT) contrast nanoagent has significant applications in diagnosing tumors. However, the sensitive differentiation between hepatoma and normal liver tissue remains challenging. This challenge arises primarily because both normal liver and hepatoma tissues capture the nanoagent, resulting in similar positive CT contrasts. Here, a strategy for fusing positive and negative CT contrast nanoagent is proposed to detect hepatoma. A nanoagent Hf-MOF@AB@PVP initially generates a positive CT contrast signal of 120.3 HU in the liver. Subsequently, it can specifically respond to the acidic microenvironment of hepatoma to generate H₂ , further achieving a negative contrast of -96.0 HU. More importantly, the relative position between the negative and positive signa

SUBMITTER: Meng X 

PROVIDER: S-EPMC10700169 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature