Supramolecularly Engineered Conjugate of Bacteria and Cell Membrane-Coated Magnetic Nanoparticles for Enhanced Ferroptosis and Immunotherapy of Tumors.

ABSTRACT: Although various ferroptosis inducers including magnetic nanoparticles (Fe₃ O₄ ) and iron-organic frameworks have been applied in cancer treatment, the mild immunogenicity, low targeting efficiency to the tumor, and poor tissue penetration have limited the therapeutic efficacy. Herein, a supramolecularly engineered conjugate between living bacteria (facultative anaerobic Salmonella typhimurium VNP20009, VNP) and cancer cell membranes-coated Fe₃ O₄ nanoparticles is developed for improving targeted delivery of Fe₃ O₄ nanoparticles into the tumor tissue and for synergistic ferroptosis and immunotherapy of tumor. The enhanced ferroptosis induced by both Fe₃ O₄ nanoparticles and the loaded ferroptosis induci

SUBMITTER: Xie B 

PROVIDER: S-EPMC10700203 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature