HPV-associated head and neck cancer is characterized by distinct profiles of CD8⁺ T cells and myeloid-derived suppressor cells.

ABSTRACT: Patients with HPV^--localized head and neck cancer (HNC) show inferior outcomes after surgery and radiochemotherapy compared to HPV-associated cancers. The underlying mechanisms remain elusive, but differences in immune status and immune activity may be implicated. In this study, we analyzed immune profiles of CD8⁺ T cells and myeloid-derived suppressor cells (MDSC) in HPV⁺ versus HPV^- disease.The overall frequency of CD8⁺ T cells was reduced in HNC versus healthy donors but substantially increased after curative therapy (surgery and/or radiochemotherapy). In HPV⁺ patients, this increase was associated with significant induction of peripheral blood CD8⁺/CD45RA^-/CD62L^- effector memory cells. Th

SUBMITTER: Kansy BA 

PROVIDER: S-EPMC10700222 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature