Mosaic chromosomal alterations in peripheral blood leukocytes of children in sub-Saharan Africa.

ABSTRACT: In high-income countries, mosaic chromosomal alterations in peripheral blood leukocytes are associated with an elevated risk of adverse health outcomes, including hematologic malignancies. We investigate mosaic chromosomal alterations in sub-Saharan Africa among 931 children with Burkitt lymphoma, an aggressive lymphoma commonly characterized by immunoglobulin-MYC chromosomal rearrangements, 3822 Burkitt lymphoma-free children, and 674 cancer-free men from Ghana. We find autosomal and X chromosome mosaic chromosomal alterations in 3.4% and 1.7% of Burkitt lymphoma-free children, and 8.4% and 3.7% of children with Burkitt lymphoma (P-values = 5.7×10^-11 and 3.74×10^-2, respectively). Autosomal mosaic chromosomal alterations are detected in 14.0% of Ghanaian men and incre

SUBMITTER: Zhou W 

PROVIDER: S-EPMC10700489 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature