XQTLbiolinks: a comprehensive and scalable tool for integrative analysis of molecular QTLs.

ABSTRACT: Genome-wide association studies (GWAS) have identified thousands of disease-associated non-coding variants, posing urgent needs for functional interpretation. Molecular Quantitative Trait Loci (xQTLs) such as eQTLs serve as an essential intermediate link between these non-coding variants and disease phenotypes and have been widely used to discover disease-risk genes from many population-scale studies. However, mining and analyzing the xQTLs data presents several significant bioinformatics challenges, particularly when it comes to integration with GWAS data. Here, we developed xQTLbiolinks as the first comprehensive and scalable tool for bulk and single-cell xQTLs data retrieval, quality control and pre-processing from public repositories and our integrated resource. In addition, xQTLbiolin

SUBMITTER: Ding R 

PROVIDER: S-EPMC10701093 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature