Burden of grade 3 or 4 liver injury associated with immune checkpoint inhibitors.

ABSTRACT:

Background & aims

There is concern about the burden of liver injury in patients with cancer exposed to immune checkpoints inhibitors (ICIs).

Methods

In a retrospective cohort study, we evaluated the likelihood of grade 3/4 liver injury, of grade 3/4 cholestatic liver injury, and of liver failure, as per the Common Terminology Criteria for Adverse Events (CTCAE) version 5, following treatment with ICIs. We compared these occurrences with a group of cancer patients who were propensity-matched and treated with conventional chemotherapy. For all ICI patients experiencing grade 3/4 liver injury, we conducted a causality assessment using the RUCAM method and examined patient outcomes.

Results

Among 952 patients (median [IQR] age 66 [57-73] years, 64% males) who were treated

SUBMITTER: Parlati L 

PROVIDER: S-EPMC10701119 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature