Variance estimation for logistic regression in case-cohort studies.

ABSTRACT:

Background

The logistic regression analysis proposed by Schouten et al. (Stat Med. 1993;12:1733-1745) has been a standard method in current statistical analysis of case-cohort studies, and it enables effective estimation of risk ratio from selected subsamples, with adjustment of potential confounding factors. Schouten et al. (1993) also proposed the standard error estimate of the risk ratio estimator can be calculated by the robust variance estimator, and this method has been widely adopted.

Methods and results

We show that the robust variance estimator does not account for the duplications of case and subcohort samples and generally has certain bias, i.e., inaccurate confidence intervals and P-values are possibly obtained. To address the invalid statistical inference proble

SUBMITTER: Noma H 

PROVIDER: S-EPMC10701255 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature