Pan-cancer analysis of 60S Ribosomal Protein L7-Like 1 (RPL7L1) and validation in liver hepatocellular carcinoma.

ABSTRACT:

Background and aims

There is an association between cancer and increased ribosome biogenesis. At present, the RPL7L1 (60S Ribosomal Protein L7-Like 1) were less reported by literature search. Study reports that RPL7L1 is associated with mouse embryonic and skeletal muscle. The study of RPL7L1 on tumors has not been reported.

Methods

Our team downloaded the pan-cancer dataset that is uniformly normalized from the UCSC database (N=19131). Our study examined the relationship between RPL7L1 expression level and clinical prognosis with methylation, anti-tumour immunity, functional states, MSI, TMB, DNSss, LOH and chemotherapeutic responses in 43 cancer types and subtypes.

Results and conclusions

RPL7L1 was overexpressed in nine tumor types. Gene mutation, tumor microenviro

SUBMITTER: He KJ 

PROVIDER: S-EPMC10701367 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature