Tetraarsenic tetrasulfide triggers ROS-induced apoptosis and ferroptosis in B-cell acute lymphoblastic leukaemia by targeting HK2.

ABSTRACT:

Purpose

Acute lymphoblastic leukemia (ALL) is the most common type of cancer diagnosed in children. Despite cure rates of higher than 85 %, refractory or relapsed ALL still exhibits a bleak prognosis indicative of the dearth of treatment modalities specific for relapsed or refractory ALL. Prior research has implicated metabolic alterations in leukemia pathogenesis, and literature on the therapeutic efficacy of arsenic compounds targeting metabolic pathways in B-cell acute lymphoblastic leukemia (B-ALL) cells is scarce.

Methods

A compound extracted from realgar, tetraarsenic tetrasulfide (As₄S₄), and its antitumor effects on B-ALL were experimentally examined in vitro and in vivo.

Results

As₄S₄ apparently targets B-ALL cells

SUBMITTER: Bai W 

PROVIDER: S-EPMC10701457 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature