Characterizing Olfactory Dysfunction in Patients with Unilateral Cleft Lip Nasal Deformities.

ABSTRACT: Background: Unilateral cleft lip nasal deformity (uCLND) is associated with olfactory dysfunction, but the underlying etiology remains poorly understood. Objective: To investigate the etiology of uCLND-associated olfactory dysfunction using clinical, computational, and histologic assessments. Methods: Inclusion criteria: uCLND patients >16 years undergoing septorhinoplasty. Exclusion criteria: prior septoplasty or rhinoplasty, pregnancy, sinusitis. Measured outcomes: patient-reported scores, rhinomanometry, smell identification and threshold tests, computational fluid dynamics (CFD) airflow simulations, and histologic analysis of olfactory epithelium. Results: Five uCLND subjects were included: 18-23 years, three male and two female, four left-sided cleft and on

SUBMITTER: Russel SM 

PROVIDER: S-EPMC10701508 | biostudies-literature | 2023 Nov-Dec

REPOSITORIES: biostudies-literature