The Effect of Growth Factors on Vaginal Wound Healing: A Systematic Review and Meta-analysis.

ABSTRACT: Surgical outcomes of pelvic organ prolapse (POP) surgery are poor, resulting in a 20% recurrence risk. Following the hypothesis that impaired wound healing is the main determinant of recurrent POP, growth factors have the potential to promote wound healing and may improve surgical outcomes. In this study, we systematically reviewed the effect of growth factors on vaginal wound healing in both in vitro and animal studies. For each independent comparison, the standardized mean difference and 95% CI were calculated using the Hedges' g correction. Of the 3858 retrieved studies, seven studies were included, of which six were included in meta-analysis (three in vitro studies and four in vivo studies). In vitro, basic fibroblast growth factor (bFGF) promotes proliferat

SUBMITTER: van Velthoven MJJ 

PROVIDER: S-EPMC10701546 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature