Disease burden and predictors associated with non-response to antihistamine-based therapy in chronic spontaneous urticaria.

ABSTRACT:

Background

H1-antihistamines (H1AH) are the first-line treatment for chronic spontaneous urticaria (CSU), but 50% of patients have inadequate disease control at standard doses.

Objective

To assess the comorbidity burden and healthcare resource utilization (HRU) associated with non-response to H1AH-based treatments; to identify predictors of non-response.

Methods

Optum® de-identified Electronic Health Record dataset (2007-2020) was used to identify adult patients with CSU who initiated a H1AH, alone or in combination with other oral non-biologics (index treatment). Based on twelve-month treatment patterns observed after index treatment initiation, patients were categorized as responders (continued index treatment or had only 1 next H1AH treatment without corticosteroid

SUBMITTER: Soong W 

PROVIDER: S-EPMC10701591 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature