Environmental bisphenol A exposure triggers trained immunity-related pathways in monocytes.

ABSTRACT:

Introduction

Trained Immunity represents a novel revolutionary concept of the immunological response involving innate immune cells. Bisphenol A is a well-known endocrine disrupter, widely disseminated worldwide and accumulated in the human body. Due to the increased interest regarding the effects of plastic-derived compounds on the immune system, our purpose was to explore whether BPA was able to induce trained immunity in human primary monocytes in vitro using low environmental concentrations.

Materials and methods

We extracted BPA from the serum of 10 healthy individuals through a liquid-liquid extraction followed by a solid phase extraction and measured the concentration using an HPLC system coupled to a triple quadrupole mass spectrometer. In parallel, monocytes w

SUBMITTER: Dallio M 

PROVIDER: S-EPMC10701735 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature