TPD52L2 as a potential prognostic and immunotherapy biomarker in clear cell renal cell carcinoma.

ABSTRACT:

Background

Tumor Protein D52-Like 2 (TPD52L2) is a tumor-associated protein that participates in B-cell differentiation. However, the role of TPD52L2 in the pathological process of clear cell renal cell carcinoma (ccRCC) is unclear.

Methods

Multiple omics data of ccRCC samples were obtained from public databases, and 5 pairs of ccRCC tissue samples were collected from the operating room. Wilcox, chi-square test, Kaplan-Meier method, receiver operating characteristic curve, regression analysis, meta-analysis, and correlation analysis were used to clarify the relationship of TPD52L2 with clinical features, prognosis, and immune microenvironment. Functional enrichment analysis was performed to reveal the potential pathways in which TPD52L2 participates in the progression of ccR

SUBMITTER: Wang H 

PROVIDER: S-EPMC10701739 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature