Ex vivo mapping of enhancer networks that define the transcriptional program driving melanoma metastasis.

ABSTRACT: Mortality from vmelanoma is associated with metastatic disease, but the mechanisms leading to spreading of the cancer cells remain obscure. Spatial profiling revealed that melanoma is characterized by a high degree of heterogeneity, which is established by the ability of melanoma cells to switch between different phenotypical stages. This plasticity, likely a heritage from embryonic pathways, accounts for a relevant part of the metastatic potential of these lesions, and requires the rapid and efficient reorganization of the transcriptional landscape of melanoma cells. A large part of the non-coding genome cooperates to control gene expression, specifically through the activity of enhancers (ENHs). In this study, we aimed to identify ex vivo the network of active ENHs and to outline their c

SUBMITTER: Manicardi V 

PROVIDER: S-EPMC10701766 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature