Multi-omics analysis of fecal microbiota transplantation's impact on functional constipation and comorbid depression and anxiety.

ABSTRACT:

Background

Depression and anxiety are common comorbid diseases of constipation. Fecal microbiota transplantation (FMT) significantly relieves gastrointestinal-related symptoms, but its impact on psychiatric symptoms remains uncharted.

Methods

We collected fecal and serum samples before and after FMT from 4 functional constipation patients with psychiatric symptoms and corresponding donor stool samples. We categorized the samples into two groups: before FMT (Fb) and after FMT (Fa). Parameters associated with constipation, depression, and anxiety symptoms were evaluated. Metagenomics and targeted neurotransmitter metabolomics were performed to investigate the gut microbiota and metabolites. 5-hydroxytryptamine (5-HT) biosynthesis was detected in patients' fecal supernatants ex

SUBMITTER: Yang C 

PROVIDER: S-EPMC10701952 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature