The age-specific comorbidity burden of mild cognitive impairment: a US claims database study.

ABSTRACT:

Background

Identifying individuals with mild cognitive impairment (MCI) who are likely to progress to Alzheimer's disease and related dementia disorders (ADRD) would facilitate the development of individualized prevention plans. We investigated the association between MCI and comorbidities of ADRD. We examined the predictive potential of these comorbidities for MCI risk determination using a machine learning algorithm.

Methods

Using a retrospective matched case-control design, 5185 MCI and 15,555 non-MCI individuals aged ≥50 years were identified from MarketScan databases. Predictive models included ADRD comorbidities, age, and sex.

Results

Associations between 25 ADRD comorbidities and MCI were significant but weakened with increasing age groups. The odds ratios (MCI

SUBMITTER: Li G 

PROVIDER: S-EPMC10701954 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature