Comparative genomic analysis of clinical Enterococcus faecalis distinguishes strains isolated from the bladder.

ABSTRACT:

Background

Enterococcus faecalis is the most commonly isolated enterococcal species in clinical infection. This bacterium is notorious for its ability to share genetic content within and outside of its species. With this increased proficiency for horizontal gene transfer, tremendous genomic diversity within this species has been identified. Many researchers have hypothesized E. faecalis exhibits niche adaptation to establish infections or colonize various parts of the human body. Here, we hypothesize that E. faecalis strains isolated from the human bladder will carry unique genomic content compared to clinical strains isolated from other sources.

Results

This analysis includes comparison of 111 E. faecalis genomes isolated from bladder, urogenital, blood, and fecal samples.

SUBMITTER: Hochstedler-Kramer BR 

PROVIDER: S-EPMC10701997 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature