Identifying tumor cell-released extracellular vesicles as biomarkers for breast cancer diagnosis by a three-dimensional hydrogel-based electrochemical immunosensor.

ABSTRACT: Tumor cell-released LC3⁺ extracellular vesicles (LC3⁺ EVs) participate in immunosuppression during autophagy and contribute to the occurrence and development of breast cancer. In view of the strong association between the LC3⁺ EVs and breast cancer, developing an effective strategy for the quantitative detection of LC3⁺ EVs levels with high sensitivity to identify LC3⁺ EVs as new biomarkers for accurate diagnosis of breast cancer is crucial, but yet not been reported. Herein, an ultrasensitive electrochemical immunosensor is presented for the quantitative determination of LC3⁺ EVs using a three-dimensional graphene oxide hydrogel-methylene blue composite as a redox probe, showing a low detection limit and a wide linear range

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10701998 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature