Comparison between canine and porcine models of chronic deep venous thrombosis.

ABSTRACT:

Objective

To first induce chronic deep venous thrombosis in the left iliac veins of canines and porcines and then compare these two models to validate endovascular treatment devices.

Methods

Thrombin and fibrinogen were used to produce a solid thrombus in the left iliac veins of a stenosis model. The researchers used venous angiography and histological staining to investigate the progression of thrombosis.

Results

A left iliac vein thrombus was successfully formed in all experimental animals, including six Labrador dogs and three Bama miniature pigs, and there was minimal surgical bleeding. All dogs survived until 90 days, and three pigs died on Days 29, 33, and 58.

Conclusion

The researchers first established the models and then observed the progression of chr

SUBMITTER: Wang C 

PROVIDER: S-EPMC10702023 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature