Increased circulating FGF21 level predicts the burden of metabolic demands and risk of vascular diseases in adults with type 2 diabetes.

ABSTRACT:

Objectives

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by chronic hyperglycemia and metabolic stress, involved in the stepwise development of cardiovascular complications. Fibroblast growth factor 21 (FGF21) is a novel hepatokine involved in regulating glucose and lipid metabolism, and has been linked to the prediction, treatment, and improvement of prognosis in multiple cardiovascular diseases (CVDs). The aim of this study is to explore the relationship between FGF21 levels and vascular diseases (VDs) including carotid atherosclerosis (CAS) and hypertension (HP) in patients with T2DM.

Methods

Baseline serum FGF21 was determined in a cross-sectional study of 701 patients with T2DM and 258 healthy control.

Results

The morbidity of CAS

SUBMITTER: Liu Z 

PROVIDER: S-EPMC10702049 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature