Clinical phenotypes and prognoses of microscopic polyangiitis based on kidney biopsies.

ABSTRACT:

Background

To classify the different clinical phenotypes and compare the distinct prognoses of microscopic polyangiitis (MPA).

Methods

A retrospective analysis of 436 patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) from 2015 to 2022 was conducted in our center, of which 90 patients were diagnosed with MPA and underwent renal biopsy.

Results

Among the 90 MPA patients, 63% were female, and the median age at onset was 63 years (25th-75th percentile: 58-68). The median follow-up time was 26 months (25th-75th percentile: 10-53). We identified four subtypes: renal impairment type (cluster 1, 39%), pure type (cluster 2, 22%), systemic inflammation type (cluster 3, 26%), and rapid progress type (cluster 4, 13%). Cluster 1, characterized

SUBMITTER: Wang J 

PROVIDER: S-EPMC10702060 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature