Pathological progress and remission strategies of osteoarthritic lesions caused by long-term joint immobilization.

ABSTRACT:

Objective

While joint immobilization is a useful repair method for intra-articular ligament injury and periarticular fracture, prolonged joint immobilization can cause multiple complications. A better understanding how joint immobilization and remobilization impact joint function and homeostasis will help clinicians develop novel strategies to reduce complications.

Design

We first determined the effects of long-term immobilization on joint pain and osteophyte formation in patients after an extraarticular fracture or ligament injury. We then developed a mouse model of joint immobilization and harvested the knee joint samples at 2, 4, and 8 weeks. We further determined the effects of remobilization on recovery of the osteoarthritis (OA) lesions induced by immobilization in mic

SUBMITTER: Gan D 

PROVIDER: S-EPMC10702075 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature