Adherence of denosumab treatment for low bone mineral density in Japanese people living with HIV: a retrospective observational study.

ABSTRACT:

Background

Long-term care issues, specifically metabolic bone disorders, are a concern for people living with human immunodeficiency virus (PLWH) who undergo life-long antiretroviral therapy (ART). Previous clinical trials with denosumab, an anti-RANKL antibody inhibitor, have revealed its effectiveness in increasing bone mineral density (BMD) in patients with osteoporosis. However, there are limited data on adherence and effectiveness of denosumab treatment for osteoporosis in PLWH. Hence, this study aimed to investigate the adherence and effectiveness of denosumab treatment for osteoporosis in Japanese PLWH.

Methods

This study is a retrospective exploratory analysis of 29 Japanese PLWH who initiated denosumab treatment for osteoporosis, between 2013 and 2021. The study inc

SUBMITTER: Kunimoto Y 

PROVIDER: S-EPMC10702095 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature