Plasma interleukin responses as predictors of outcome stratification in patients after major trauma: a prospective observational two centre study.

ABSTRACT:

Background and objectives

There is a need to develop objective risk stratification tools to define efficient care pathways for trauma patients. Biomarker-based point of care testing may strengthen existing clinical tools currently available for this purpose. The dysregulation of pro- and anti-inflammatory cytokines in the pathogenesis of organ failure is well recognised. This study was carried out to evaluate whether blood concentrations of IL-6, IL-10, and IL-6:IL-10 ratios in the early stages of the illness are significantly different in patients with worsening organ function.

Materials and methods

In this prospective observational cohort study, plasma concentrations of IL-6 and IL-10 on days 1, 3 and 5 were measured in 91 major trauma patients using a multiplexed cytometr

SUBMITTER: Jones MA 

PROVIDER: S-EPMC10702136 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature