Disrupting nociceptive information processing flow through transcranial focused ultrasound neuromodulation of thalamic nuclei.

ABSTRACT:

Background

MRI-guided transcranial focused ultrasound (MRgFUS) as a next-generation neuromodulation tool can precisely target and stimulate deep brain regions with high spatial selectivity. Combined with MR-ARFI (acoustic radiation force imaging) and using fMRI BOLD signal as functional readouts, our previous studies have shown that low-intensity FUS can excite or suppress neural activity in the somatosensory cortex.

Objective

To investigate whether low-intensity FUS can suppress nociceptive heat stimulation-induced responses in thalamic nuclei during hand stimulation, and to determine how this suppression influences the information processing flow within nociception networks.

Findings

BOLD fMRI activations evoked by 47.5 °C heat stimulation of hand were detected in 2

SUBMITTER: Mishra A 

PROVIDER: S-EPMC10702144 | biostudies-literature | 2023 Sep-Oct

REPOSITORIES: biostudies-literature