Gut microbiota and risk of lower respiratory tract infections: a bidirectional two-sample Mendelian randomization study.

ABSTRACT:

Introduction

Observational studies have reported the association between gut microbiota and the risk of lower respiratory tract infections (LRTIs). However, whether the association reflects a causal relationship remains obscure.

Methods

A bidirectional twosample Mendelian randomization (MR) analysis was conducted by assessing genome-wide association study (GWAS) summary statistics for gut microbiota taxa and five common LRTIs. MR methods including inverse-variance-weighted (IVW), MR-Egger, weighted median, simple mode, and weighted mode were used to analyze the causality. Gene pleiotropy was tested using MR-Egger regression and MR-PRESSO methods. Cochran's Q test was used to check for heterogeneity. Leave-one-out analysis was used to assess the stability of effect sizes. Det

SUBMITTER: Liu W 

PROVIDER: S-EPMC10702245 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature