Cytogenotoxic potential and toxicity in adult Danio rerio (zebrafish) exposed to chloramine T.

ABSTRACT:

Background

Chloramine-T (CL-T) is a synthetic sodium salt used as a disinfectant in fish farms to combat bacterial infections in fish gills and skin. While its efficacy in pathogen control is well-established, its reactivity with various functional groups has raised concerns. However, limited research exists on the toxicity of disinfection by-products to aquatic organisms. Therefore, this study aims to assess the sublethal effects of CL-T on adult zebrafish by examining biomarkers of nucleus cytotoxicity and genotoxicity, acetylcholinesterase (AChE) inhibition, and histopathological changes.

Methods

Male and female adult zebrafish (wildtype AB lineage) specimens were exposed to 70, 140, and 200 mg/L of CL-T and evaluated after 96 h. Cytotoxic and genotoxic effects were evalu

SUBMITTER: Rivero-Wendt CLG 

PROVIDER: S-EPMC10702335 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature