Expansion of CD4+ cytotoxic T lymphocytes with specific gene expression patterns may contribute to suppression of tumor immunity in oral squamous cell carcinoma: single-cell analysis and in vitro experiments.

ABSTRACT:

Background

Cancer immunotherapy targeting CD8⁺ T cells has made remarkable progress, even for oral squamous cell carcinoma (OSCC), a heterogeneous epithelial tumor without a substantial increase in the overall survival rate over the past decade. However, the therapeutic effects remain limited due to therapy resistance. Thus, a more comprehensive understanding of the roles of CD4⁺ T cells and B cells is crucial for more robust development of cancer immunotherapy.

Methods

In this study, we examined immune responses and effector functions of CD4⁺ T cells, CD8⁺ T cells and B cells infiltrating in OSCC lesions using single-cell RNA sequencing analysis, T cell receptor (TCR) and B cell receptor (BCR) repertoire sequencing analysis, and m

SUBMITTER: Chen H 

PROVIDER: S-EPMC10702345 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature