Causal relationship between gut microbiota and immune thrombocytopenia: a Mendelian randomization study of two samples.

ABSTRACT:

Background

Some observational studies have shown that immune thrombocytopenia (ITP) is highly associated with the alteration-composition of gut microbiota. However, the causality of gut microbiota on ITP has not yet been determined.

Methods

Based on accessible summary statistics of the genome-wide union, the latent connection between ITP and gut microbiota was estimated using bi-directional Mendelian randomization (MR) and multivariable MR (MVMR) analyses. Inverse variance weighted (IVW), weighted median analyses, and MR-Egger regression methods were performed to examine the causal correlation between ITP and the gut microbiota. Several sensitivity analyses verified the MR results. The strength of causal relationships was evaluated using the MR-Steiger test. MVMR analysis wa

SUBMITTER: Guo D 

PROVIDER: S-EPMC10702357 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature