Family screening for bicuspid aortic valve and aortic dilatation: a meta-analysis.

ABSTRACT:

Aims

International guidelines recommend screening of first-degree relatives (FDR) of people with bicuspid aortic valves (BAVs). However, the prevalence of BAV and of aortic dilatation amongst family members is uncertain.

Methods and results

A systematic review and meta-analysis of original reports of screening for BAV. Databases including MEDLINE, Embase, and Cochrane CENTRAL were searched from inception to December 2021 using relevant search terms. Data were sought on the screened prevalence of BAV and aortic dilatation. The protocol was specified prior to the searches being performed, and standard meta-analytic techniques were used. Twenty-three observational studies met inclusion criteria (n = 2297 index cases; n = 6054 screened relatives). The prevalence of BAV amongst r

SUBMITTER: Bray JJH 

PROVIDER: S-EPMC10702468 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature