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Integration of liquid biopsy and immunotherapy: opening a new era in colorectal cancer treatment.

ABSTRACT: Immunotherapy has revolutionized the conventional treatment approaches for colorectal cancer (CRC), offering new therapeutic prospects for patients. Liquid biopsy has shown significant potential in early screening, diagnosis, and postoperative monitoring by analyzing circulating tumor cells (CTC) and circulating tumor DNA (ctDNA). In the era of immunotherapy, liquid biopsy provides additional possibilities for guiding immune-based treatments. Emerging technologies such as mass spectrometry-based detection of neoantigens and flow cytometry-based T cell sorting offer new tools for liquid biopsy, aiming to optimize immune therapy strategies. The integration of liquid biopsy with immunotherapy holds promise for improving treatment outcomes in colorectal cancer patients, enabling breakthroughs in early diagnosis and treatment, and providing patients with more personalized, precise, and effective treatment strategies.

SUBMITTER: Yao S

PROVIDER: S-EPMC10702507 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Integration of liquid biopsy and immunotherapy: opening a new era in colorectal cancer treatment.

Yao Shiya S Han Yuejun Y Yang Mengxiang M Jin Ketao K Lan Huanrong H

Frontiers in immunology 20231121

Immunotherapy has revolutionized the conventional treatment approaches for colorectal cancer (CRC), offering new therapeutic prospects for patients. Liquid biopsy has shown significant potential in early screening, diagnosis, and postoperative monitoring by analyzing circulating tumor cells (CTC) and circulating tumor DNA (ctDNA). In the era of immunotherapy, liquid biopsy provides additional possibilities for guiding immune-based treatments. Emerging technologies such as mass spectrometry-based ...[more]

PMID: 38077354

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Liquid biopsy approaches and immunotherapy in colorectal cancer for precision medicine: Are we there yet?

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