Integrating serum pharmacochemistry and network pharmacology to reveal the active constituents and mechanism of Corydalis Rhizoma in treating Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease (AD) is a multifactorial neurodegenerative condition. The search for multi-target traditional Chinese medicines or ingredients for treating AD has attracted much attention. Corydalis rhizome (CR) is a traditional Chinese medicine. Its main components are alkaloids, which have therapeutic effects that can potentially be used for treating AD. However, no systematic study has been conducted to explore the anti-AD efficacy of CR, as well as its active compounds and mechanisms of action.

Objective

The present study aimed to clarify CR's active constituents and its pharmacological mechanisms in treating AD.

Methods

A D-galactose & scopolamine hydrobromide-induced AD mouse model was used and CR was administered orally. The prototypical alkaloid

SUBMITTER: Lyu Y 

PROVIDER: S-EPMC10702756 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature