Association between oral microbiome and seven types of cancers in East Asian population: a two-sample Mendelian randomization analysis.

ABSTRACT: Background: The oral microbiome has been intricately linked to various pathological conditions, notably cancer, though clear causal links remain elusive. This study aimed to investigate the potential causal relationships between the oral microbiome and seven major cancers: breast, lung, pancreatic, colorectal, gastric, ovarian, and prostate cancers, leveraging Mendelian randomization (MR). Methods: A two-sample MR analysis was conducted using genome-wide association study (GWAS) data specific to oral microbiota in individuals of East Asian descent. Single nucleotide polymorphisms (SNPs) independent of confounders served as instrumental variables (IVs) to deduce causality. MR methodologies such as the inverse variance weighted (IVW) method, weighted median (WM) method, and Men

SUBMITTER: Feng K 

PROVIDER: S-EPMC10702768 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature