Ontogenesis of the Mouse Ocular Surface Lymphatic Vascular Network.

ABSTRACT:

Purpose

Ocular lymphatic vessels play major physiological role in eye homeostasis and their dysfunction can contribute to the progression of several eye diseases. In this study, we characterized their spatiotemporal development and the cellular mechanisms occurring during their ontogenesis in the mouse eye.

Methods

Whole mount immunofluorescent staining and imaging by standard or lightsheet fluorescence microscopy were performed on late embryonic and early postnatal eye mouse samples.

Results

We observed that the ocular surface lymphatic vascular network develops at the early postnatal stages (between P0 and P5) from two nascent trunks arising at the nasal side on both sides of the nictitating membrane. These nascent vessels further branch and encircle the whole eye s

SUBMITTER: Subileau M 

PROVIDER: S-EPMC10702784 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature