Prenatal metal mixture exposure and birth weight: A two-stage analysis in two prospective cohort studies.

ABSTRACT: The understanding of the impact of prenatal exposure to metal mixtures on birth weight is limited. We aimed to identify metal mixture components associated with birth weight and to determine additional pairwise interactions between metals showing such associations. Concentrations of 18 metals were measured using inductively coupled plasma mass spectrometry in urine samples collected in the 3rd trimester from a prenatal cohort (discovery; n = 1849) and the Healthy Baby Cohort (replication; n = 7255) in Wuhan, China. In the discovery set, we used two penalized regression models, i.e., elastic net regression for main effects and a lasso for hierarchical interactions, to identify important mixture components associated with birth weight, which were then replicated. We observed that 8 of the 18

SUBMITTER: Hu J 

PROVIDER: S-EPMC10702918 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature