PFOS-elicited metabolic perturbation in liver and fatty acid metabolites in testis of adult mice.

ABSTRACT:

Introduction

Multiple factors can contribute to sub-fecundity, including genetics, lifestyle, and environmental contaminants. PFASs are characterized as "forever chemicals" due to their ubiquitous contamination and their persistence in the environment, wildlife, and humans. Numerous studies have demonstrated that PFAS exposure adversely affects multiple bodily functions, including liver metabolism and gonadal function. It is unclear, however, how the disruption of hepatic fatty acid metabolism affects testicular function.

Methods

In this study, male mice were administered 0.3 and 3 μg/g body weight of PFOS for 21 days.

Results

Our data showed that PFOS exposure caused hepatic steatosis, as evidenced by significant increases in triglyceride levels, expression of ATP-ci

SUBMITTER: Lee WK 

PROVIDER: S-EPMC10703039 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature