Impact of youth onset type 2 diabetes during pregnancy on microvascular and cardiac outcomes.

ABSTRACT:

Aims

To examine the impact of pregnancy on microvascular and cardiovascular measures in women with youth-onset T2D.

Methods

Microvascular and cardiovascular measures were compared in in a cohort of 116 women who experienced a pregnancy of ≥ 20 weeks gestation and 291 women who did not among women in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study.

Results

Cox regression models adjusted for participant characteristics at baseline including age, race/ethnicity, household income, diabetes duration, HbA1c (>6%), and BMI, demonstrated those who experienced pregnancy had 2.76 (1.38-5.49; p = 0.004) fold increased risk of hyperfiltration (eGFR ≥ 135 ml/min/1.73 m²), compared to those without a pregnancy. No differences were observe

SUBMITTER: Tryggestad JB 

PROVIDER: S-EPMC10703062 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature