Performance of deamidated gliadin peptide antibodies as first screening for celiac disease in the general pediatric population.

ABSTRACT:

Background

Celiac serology has evolved, with the identification of newer antibodies against deamidated gliadin peptides (DGP) [e.g., anti-DGP, immunoglobulin A (IgA), and immunoglobulin G (IgG) types] with sensitivity and specificity in detecting celiac disease (CeD) that are equivalent to anti-tissue transglutaminase [anti-tissue transglutaminase (TTG) IgA]-based tests, particularly in populations with high pretest probability of CeD (prevalence of CeD > 50% of the population under study). This opens the possibility that anti-DGP assays can be used to identify CeD in the general population where the prevalence of CeD is very low (≈1%).

Objective

This study aimed (1) to determine the diagnostic performance of DGP antibodies-based serologic assays in identifying CeD during th

SUBMITTER: Al-Hussaini A 

PROVIDER: S-EPMC10703185 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature