The potential of piR-823 as a diagnostic biomarker in oncology: A systematic review.

ABSTRACT: Emerging evidence has demonstrated that PIWI-interacting RNAs (piRNAs) play important roles in various physiological processes and contribute to cancer progression. Moreover, piRNAs and PIWI protein levels are associated with the prognosis and chemoresistance of various cancers. The limitations of biomarkers challenge early detection and monitoring of chemoresistance and cancer relapse. To evaluate the potential of piRNA as a diagnostic biomarker in oncology, we systematically reviewed previous studies on the subject. PubMed, Embase, and Cochrane databases were searched to evaluate the diagnostic relevance of piRNAs in cancer. Eighteen studies (2,352 patients) were included. The quality of each study was evaluated with AMSTAR and QUADAS-2 tool. The area under the curve (AUC) values of 26 p

SUBMITTER: Sohn EJ 

PROVIDER: S-EPMC10703285 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature